Scientist I, NMR in Frederick, MD

Description

Scientist I, NMR

Job ID: req1954
Employee Type: exempt full-time
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

 Position Overview:

PROGRAM DESCRIPTION         

The Basic Science Program (BSP) pursues independent, multidisciplinary research programs in basic or applied molecular biology, immunology, retrovirology, cancer biology or human genetics.  Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR).  As part of the BSP, the Structural Biology & NMR section of the Basic Research Laboratory, under the direction of Dr. Hiroshi Matsuo, focuses on research to determine structures of protein-protein and protein-DNA or RNA complexes by using nuclear magnetic resonance spectroscopy (NMR) and X-ray crystallography.  The section also develops new techniques to overcome current limitations in studying large and complicated macromolecular complexes.

KEY ROLES/RESPONSIBILITIES

In support of these research efforts, the individual will:

• Perform laboratory research on human APOBEC3 proteins and HIV-1 Vif E3 ligase complex
• Perform hands-on benchwork with the expectation of producing first author papers
• Performance of a full range of experiments from molecular biology to structural biology
• Work will involve several projects aimed at obtain atomic-level understanding of the APOBEC3-VIf interaction
• Perform NMR spectroscopy, data analysis and structure determination of the APOBEC3G-VIf E3 ligase complex
• Develop new methods to study structure and function of large multi-protein complexes using NMR

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in chemistry, biochemistry or biophysics or eight (8) years of related experience.  Foreign degrees must be evaluated for U.S. equivalency 
• In addition to the education requirement, 0-2 years responsible experience
• Experience in three dimensional triple resonance NMR spectroscopy, expression and purification of stable isotope labeled protein, protein structure determination using NMR data
• Record of first-author publications
• Scientific writing and presentation skills
• Reading and writing of NMR pulse sequences (Bruker or Varian)
• Knowledge of virology of retroviruses such as HIV and biology of ubiquitine mediated protein degradation
• Ability to obtain and maintain a security clearance

JOB HAZARDS

• This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations
• This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

#readytowork