Job Details - Scientist - 34871993 | Frederick National Laboratory Talent Network
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Scientist II, Electron Microscopist in Frederick, MD

Location: Frederick, MD
Career Level: Entry Level
Industries: Healthcare, Pharmaceutical, Biotech


Scientist II, Electron Microscopist

Job ID: req1413
Employee Type: exempt full-time
Facility: ATRF: Other
Location: 8560 Progress Drive, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public's interest.  

 Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.


  • Provide technical advice to investigators on sample preparation, and data collection
  • Operate TEM microscopes, specifically Titan Krios and Talos Arctica; task will include loading samples, screening, and performing high-resolution data collection for single particle studies as well as cryo-electron tomography
  • Manage and use CryoSPARC live software as well as other software related to EM (Relion, IMOD, Amira…)
  • Manage maintenance for the Titan Krios and the Talos Arctica as well as associated instruments (T20, Talos L120C)
  • Train new CMM employees and other users in the use of the Krios, Tecnai T20 and Talos L120C as well as in data collection software and in the sample preparation techniques
  • Interact closely with colleagues within the CMM as well as other groups


  • Possession of a master's degree or a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation in Biological Sciences, Structural Biology, or related discipline (Foreign degrees must be evaluated for U.S. equivalency)
  • Minimum of two (2) years of experience with Cryo-EM, Cryo-electron tomography, and high-resolution single-particle analysis
  • Must be detail-oriented and able to manage multiple projects simultaneously
  • Able to prepare detailed, concise technical reports
  • Strong laboratory skills
  • Must be able to obtain and maintain a clearance


  • Experience with negative stain and other specimen preparation techniques for EM
  • Experience in Micro-ED


  • This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)


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